Relaxing Muscle May Lock Fibromyalgia Symptoms
Low doses of cyclobenzaprine relaxing the muscle, taken at bedtime, assist fibromyalgia-relaxed individuals to sleep better and feel less pain, according to a tiny study. “Seth Lederman, MD, president of TONIX Pharmaceuticals, who financed the research, said that the medical therapy for patients who received low-dose cyclobenzaprine was secure and seemingly efficient.” About fibromyalgia is 5 million Americans.
For patients with fibromyalgia at higher levels like Amrix, Fexmid, and Flexeril, Lederman says, cyclobenzaprine is already frequently used off-label. Off-label ‘ refers to drugs for conditions not specifically authorized by the FDA.
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Therefore TONIX develops and improves the formula, claims Lederman, on a lower dose variant.
However, a non-study-related rheumatologist does not expect that the fresh medication will be a “game-changer.”
The results of the studies are published in the Rheumatology Journal online.
Understanding Fibro Treatments
However, Lederman and the University of Toronto’s other scientists randomly allocated 18 cyclobenzaprine patients with fibromyalgia at a dose of 1 milligram per day, with 18 patients allocated to placebo.
If required the dose is increased. Some other products come with cyclobenzaprine as 5 milligrams or 10 milligrams tablets.
The 8-week survey was finalized in 29 patients. In the end, the scientists found the quality of sleep improved. The average time of sleep in the treating group increased from 5.7 to 6.4 hours. Tiredness slightly decreased.
Due to the research, pain in the group of drugs fell by 26 percent. This was 18% higher than in the placebo group.
Therefore in the medication group, tenderness was enhanced by 30%. This was 16% higher than in the position group. Tenderness influences particular touch-sensitive points in the body.
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So, the medication group had depression decreased by 22%— 38% higher than in the placebo group.
However, for both groups, the reported side effects were comparable. The most frequent neighborly impact in the drug group was headaches. Some people also had dry mouths and somnolence.
Three additional medicines have been approved for fibromyalgia medicines, but Lederman says all of them are daily. For fibromyalgia treatment, no medication approved yet. Higher doses of muscle relaxants can sometimes lead to excessive sleepiness during the day, Lederman claims. A lack of sleep is thought to exacerbate the symptoms of fibromyalgia. As the study has indicated, the symptoms can increase during the day when sleep is restored.
More research is necessary to check whether the fresh treatments are better than current ones.
Therefore Lederman suggests that if everything goes well, the medicine could be on the market in 2015. There is no estimate of the costs of the medicine.
Therefore the results are not surprising to Brian Walitt, MD, MPH, assistant professor of pharmacology at Georgetown University. Because he examined the results of the Web® study but did not participate in the studies.
“If you have fibromyalgia, are you really 18 percent better?” Walitt, who is also an associate director of rheumatology at Washington Hospital Center, adds, “if allowed, a new dose of medication is not going to substantially change the materials for people with fibromyalgia.”, “says Walitt.
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