NSAIDs for Fibromyalgia & Chronic Fatigue Syndrome

By: Dr Alexa James

The lack of inflamamtory findings

When patients complain about diffuse muscle and soft tissue pain in the tender areas, fibromyalgia (FM) diagnosis is considered. Pure or primary FM is non-inflammatory because it has poor response to anti-inflammatory conditions and has a lack of inflammatory findings about blood work, and examination. It is not associated with other inflammatory diseases. However, there can be diffuse musculoskeletal pain in patients with inflammatory disease such as RA, which feels like FM but is inflammatory, and thus likely to be inflammatory.

What are NSAIDs?

We generally refer to pain relievers available on the grocery store or on the pharmacy when talking about NSAIDs. Ibuprofen (advil and motrin), sodium naproxen (alve) and aspirin (bavarian and excedrin) include these substances.  Most people assume acetaminophen (Tylenol) is in the NSAID family, but this group of OTC drugs technically does not. Actually, acetaminophen not only has no effect on inflammation, but scientists remain uncertain about its workings.  It’s a pain killer or analgesic technically.  There are several other types of NSAID prescription, but we will focus on the most popular ones.

Pain killers are antiinflammatory medicines

Anti-inflammatory medicines are one of the most common types of painkillers. NSAIDs, which stand for non-steroidal anti-inflammatory medicinal products, are a common type of anti-inflammatory medication. Include popular OTC NSAIDs:

  • Advil, Motrin (ibuprofen)
  • Aleve, Naprosyn (naproxen)
  • Bayer, Bufferin, Excedrin (aspirin)

The prescription strengths of these drugs are also available. NSAIDs include prescription-only:

  • Relafen (nabumetone)
  • Lodine (etodolac)
  • Celebrex (celecoxib)
  • Feldene (piroxicam)
  • Orudis (ketoprofen)
  • Voltaren (diclofenac)

Not all the pain caused by fibromyalgia is due

The general pain is usually taken with Ibuprofen, naproxen sodium and aspirin. Sometimes, pain levels associated with various types of surgery are proposed to be treated. Thus, it is meaningful to consider them as a way of finding relief from fibromyalgia. The difficulty is that not all pain with fibromyalgia is due to inflammation. In fact, the absence of fibromyalgia inflammation is one of the main differences from inflammatory conditions such as rheumatoid arthritis. However, at least one study shows that fibromyalgia is inflamed by the fascia, the fibrous sheath that covers the muscles. Inflammation, however, is not an indicator of fibro-diagnosis.

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Dangers of NSAID

More than 100,000 people are admitted to hospital in the United States each year due to NSAIDs, according to the American Journal of Medicine. In addition, NSAID-related problems, like ulcers and gastrointestinal bleeding, die from 15 to 20,000 each year, and digestive side effects could occur in as many as 60% of users of NSAID. Increased risk for death from heart attack or stroke is also associated with NSAIDs. These medicines may also cause liver or kidney problems.

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Possible side effects of medicines such as Vioxx-COX-2 Inhibitors:

Fibromyalgia Pain Relief Vioxx has been developed to reduce pain and inflammations without the risk of ulcers and other potentially fatal gastrointestinal side effects of aspirin and similar medicine, called a “COX 2 inhibitor.” Fibromyalgia Pain Relief Vioxxx. But COX-2 inhibitors may cause a second in resolving one serious problem. A group of researchers led by Garret FitzGerald MD, head of the Pharmacologist and Director of the Institute of Translational Medicine and Therapeutics at Penn, found that both drugs had been suppressing prostacycline in humans just before Celebrex and Vioxx were approved and launched.

Prostaglandin

Most medical researchers agree that an anti-inflammatory drug-related pain relief is just a good benefit to their work. That is, they are preventing the synthetization of a type of lipid called prostaglandin within the body. Prostaglandins do a lot, but ultimately, they play a vital role in the inflammatory reaction process of the body.  This prevents the inflammatory response in the body from spreading or even starting.  And there is no inflammation which means no inflammatory pain.

Fibromyalgia pain is usually not primarily caused by inflammation.

Sounds awesome, okay? Not that quickly. See, the problem is that the pain caused by fibromyalgia does not usually come first. However, patients with fibro are also often affected by other conditions. Other inflammatory conditions such as arthritis react quite well to anti-inflammatory medicines. That being said, only one way can really figure out if anti-inflammatory drugs work for you: try them for yourself. Some of your pain, but not all, can be relieved. Other days, it could however be the perfect solution and provide you with the relief you need to make it pain free throughout your day. And it’s what matters if it works.

Other NSAIDS ‘ potential side effects:

Fibromyalgia Pain is 7 times more likely for adverse gastrointestinal effects for a person taking NSAIDs. The FDA estimates that 200,000 gastric bleeding cases take place every year and that 10,000 to 20,000 deaths are reported every year. The risk of developing higher blood pressure by a person is over double that of NSAIDs, which could lead to more medication. A study also included 41 percent of those who had recently begun drug use to lower blood pressure.

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Talk to your doctor

You and your doctor will decide together if your diagnoses, symptoms, overall health and lifestyle factors are suitable for NSAIDs. It is important to note that one NSAID can work for you better than others, so that experiments with different medicines can be done to produce the best results. Talk with your doctor about possible alternatives and weigh the risk against benefit when you feel that NSAIDs are effective in reducing your pain.

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Reference:

  • NSAIDs for Fibromyalgia and Chronic Fatigue Syndrome By Adrienne Dellwo via verywell health

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