Some people with rheumatoid arthritis (RA) take a disease-modifying antirheumatic drug (DMARD) and/or a biologic and reach remission. Others try drug after drug after drug and never find one that’s effective — or that treats their symptoms without causing intolerable side effects. At the same time, other patients with active disease refuse to take the most powerful and effective medications on the market or can’t take them because of their medical history or personal risk…
The anti-malarial drug lowers cholesterol and blood sugar makes blood less sticky, which is good for reducing blood clots and heart attack risk. If you take the anti-malarial drug hydroxychloroquine (Plaquenil) as part of your treatment for lupus or rheumatoid arthritis (RA), you may be getting cardiovascular protection as an added bonus. That’s welcome news because it’s estimated that about half of lupus patients experience heart complications, and heart attacks occur at younger ages in…
Screening is important because silent hepatitis B and C infections can spring to life when you start biologics or new synthetic DMARDs. Before you start taking a biologic drug or one of the new targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs), several screening tests are recommended. These include tests to see whether you have hepatitis B or C in your body that isn’t causing symptoms but might be reactivated after you start these powerful immune-suppressing drugs.…
A new study adds support to the theory that psychological stress might increase the risk of fibromyalgia and make symptoms worse. No one knows what causes fibromyalgia but some experts believe that stress may be a common trigger, especially in people who are susceptible to this chronic pain condition for physiological reasons. Now a new study adds support to the theory that psychological stress might increase the risk as well as lead to worse symptoms…
Osteoarthritis is the most common and well-known type of arthritis. It’s largely a wear-and-tear form of arthritis that happens as a result of damage to or overuse of a joint, usually over a long period of time. About 30 million Americans have osteoarthritis. You can also have osteoarthritis at the same time as other kinds of arthritis that are inflammation- or immune-related, such as rheumatoid arthritis, gout, psoriatic arthritis, or ankylosing spondylitis. How Osteoarthritis Affects…
As the temperature increased, so did the risk of rash, joint inflammation, kidney problems, and other lupus symptoms. Shifts in weather patterns have long been associated with a variety of health ailments, from seasonal allergies to migraine and joint pain. Now a new study suggests that changes in the outdoor environment may make people who have lupus more susceptible to flare-ups of specific symptoms. The study, presented at the 2019 American College of Rheumatology/Association of Rheumatology…
Researchers hope that identifying the link between respiratory issues and RA will result in better ways to prevent or screen for rheumatoid arthritis in people with lung disease. You may have already heard that people with rheumatoid arthritis (RA) are more likely to develop the serious lung disease chronic obstructive pulmonary disease (COPD), which makes it increasingly difficult to breathe. In 2017, Harvard researchers examined data from the huge Nurses’ Health Study and found that…
New data compares what happens when the dosage of DMARDs such as methotrexate is tapered or kept steady. For most rheumatoid arthritis (RA) patients, sustained remission (inactive disease) is the goal of taking methotrexate or biologic DMARDS to manage their disease. However, what to do after reaching that goal hasn’t been clear. Should RA patients stick with the medication dose that’s working or gradually taper the dose — and thus lessen both the expense of…
Knowing there could be a lag between objective measures of improvement and patient–reported outcomes could help prevent over-treatment. When a rheumatologist measures disease activity in a patient with rheumatoid arthritis (RA), objective clinical measures like C-reactive protein levels in the blood and swollen joint count are essential to factor in, but so are patient-reported measures including pain and fatigue. While both are certainly important, there may be some benefit to evaluating clinical factors and patient-reported…
Although biologics cross the placenta, research shows they lead to few infections in babies after they’re born. The prospect of pregnancy can be daunting for women with inflammatory arthritis. Not only can disease flares occur, but a host of medications — including the commonly prescribed methotrexate — are off-limits because of concerns about birth defects and complications. There’s also a worrisome information gap on the effects of many medications during pregnancy, since pregnant women are…